Signals — we see them all the time. When you drive, you get simple signals from traffic lights: go or don’t go. Traffic flows with very few accidents because these signals are obeyed (almost) always. These signals control traffic successfully because the drivers understand the meaning of the signals, are looking for the signals, and know how to respond to the signals — and most of all because the drivers voluntarily obey them.

A route, which could also be called a pathway, has a chain of signals as you go from one place to another. You go from signal to signal along the path. In your body, signals are controlling how cells interact with each other. Cells produce proteins to send signals, and have receptors that are keyed to certain proteins to receive them. Sometimes pathways in the body involve chain reactions, where one signal leads to another to get to the end result. And just like traffic, your body may turn and go down a different pathway when roadblocks or other environmental reasons suggest a different path. You may not know what exact route you are going to take to get somewhere when you start: your navigation system may predict one route, only to change it as it is informed of traffic delays on a particular road. The navigation is designed to find you the best pathway to get you to your destination based on what is happening at the moment. Likewise, signaling in your body adjusts to its environment to get you to a destination.

Cancer is known to ignore some of the body’s signals, but it is still gives, receives, and acts on signals. Otherwise it would be unable to form a colony, and the isolated cells would be easily picked off by the immune system. Like normal body cells, cancer cells are attempting to thrive in their current environment. It still has many pathways, but some are functioning differently.

The problem with drugs
Chemotherapy, like any drug, enhances or suppresses certain cell functions. It is akin to taking a sledge hammer to kill a fly, because whatever function that it targets will be disrupted throughout the body. It is toxic, cause toxins and inflammation to be produced, and does great harm to the healthy portions of the body. Some chemotherapy drugs attempt to target certain pathways which are considered to be beneficial to cancer development, but are still toxic, and are still sledgehammers, not only because they usually do more than simply disrupt the pathway, but the pathway that they target has value throughout the body and the drugs aren’t just impacting the signaling within the cancer colony. Pathways are highly complex and designed to let cells perform necessary metabolic functions.

Published in Medical Xpress, a study by City of Hope National Medical Center looked at the effects of a particular botanical on cancer, because it modulates multiple pathways. One researcher explained that modern chemotherapy targets a specific pathway, and “…It can give patients relief in the short term, but sometimes the cancer says, ‘No problem. We have 100 different ways to survive.’”

Even if we focus on a pathway that seems vital to cancer function, we learn that pathways aren’t so simple. The “Wnt pathway” regulates cell metabolism and growth rate. It is a major target of chemotherapy for that reason. Yet deeper study finds that may not work as expected. Published in Nature Communications, a study at McMaster University found that a major pathway that was considered to aid cancer development sometimes did the opposite. “Our work shows that the Wnt pathway, which has historically been considered cancer-promoting, may function as a tumor suppressor in certain contexts.” — this is a quote from one of the researchers. “In certain contexts” speaks to the complex nature of signaling pathways. Even if a drug manages to suppress a pathway as intended to supposedly damage the tumor, it may promote cancer “in certain contexts.” — that could be restated as “in certain environments.”

Environment is the only reason for cancer to form, advance, or remit. Environment triggers changes that push cells one direction or another. Well, what about drugs — don’t they have an impact too? Yes, that is because drugs act to change the body’s environment! Only environment, including every food, herb, or drug that you add to the body, changes the way cells act and signal each other.

Differences in cancer signaling and healthy signaling
The “CHAZ” protest zone in Washington that formed for a while built their own community with their own communication and function within Seattle. They kicked out the police and ignored orders to leave. They were no longer acting as part of Seattle, but instead were using the streets and buildings for their own purposes. This was not unlike cancer. Remember that cancer cells are your own body cells that are acting as rogue members of the family. They are operating within the body, using the body’s resources, but are working to build their own community rather than be a useful part of the body.

Cancer cells use angiogenic (blood supply promoting) signals like normal cells to get blood supply. They have pathways to produce enzymes and drive normal metabolic functions. They ignore signals that cause normal, end-of-life cell death, and they signal rapid cell multiplication. They don’t write a whole new set of signaling rules — they just modify signal pathways that are already in existence. This is why drugs are a sledgehammer: there is no “cancer-only” pathway that can be disrupted without affecting the rest of the body.

Epigenetics — where genetic code segments rearrange to cause a different genetic expression — is always happening as cells attempt to thrive in their existing environment. Thus, environment is the driver of epigenetic adaptation. Drugs, which are toxic, promote epigenetic adjustments to genetic function that generally favors cancer over normal healthy cell function. Disrupting pathways may also cause the cell to test other gene segment rearrangements to find a way around a blocked pathway. Eventually cancer cells will “stumble” upon a configuration that allows them to survive the chemotherapy. If this happens before the cancer has been eradicated, the cancer now knows how to resist the drugs and it multiplies unimpeded.

In conclusion, any disease treatment, including cancer, must consider the body’s environment. Does the treatment enhance or damage the environment on balance — does it do more good or harm? We know that health-promoting activities — exercise, hydration, good food, and stress reduction — all improve the environment. The last thing a cancer patient needs to do is neglect these basics. And then consider the rest of the treatment protocol — does it make for a healthy environment or a disease environment? Consider any treatment in this light.

Dr. Nemec’s Comments:
The signals for the pathways are not just proteins and molecules, they are first and foremost information coming from environment — the mental, emotional, and physical environment. When you get diagnosed with cancer, what do you think that environment produces? Fear, doubt, and stress. These are more damaging to the signaling pathways then any protein or molecule communication. What does this mean to you? To get a disease like cancer you already have made an inflammatory and toxic environment for years. To this you are going to add conventional treatment of chemotherapy and inflame and toxify that environment ten times more. My question to you is: what are you doing to heal and clean up that inflammatory environment? This is what we have done with patients for the last 36 years. If you do conventional treatment to kill cancer and make a worse environment than what produced the cancer, you sure better invest in a healing program to offset the damage done by the conventional treatment, or there is a great chance the cancer will just come back and spread into multiple areas. If I am talking to you today, and you are listening with your heart to what I am saying, and this is the approach you want to take — give us a call to schedule a consultation.

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