Even high-normal doses of the painkiller in Tylenol might be harmful, study suggests

In a new study, people who repeatedly took the maximum recommended daily dose of acetaminophen developed abnormalities in blood tests that can be a signal for liver damage.
For this study, 145 healthy adults each received either a placebo, one of three acetaminophen/opioid combinations, or acetaminophen alone for 14 days. Each active treatment included 4 grams of acetaminophen daily, the maximum recommended daily dosage.
None of the patients in the placebo group had a maximum aminotransferase (ALT and AST) tests used to measure levels of specific liver enzymes, measurement of more than 3 times the upper limit of normal.
However, in the four treatment groups, 31 percent to 44 percent of patients had a maximum ALT of more than three times the upper limits of normal. Those in the acetaminophen-alone group had a similar elevation, suggesting that the opioid had nothing to do with the effect.
-JAMA

Dr. Keith and Laurie Nemec’s comments on acetaminophen triggers liver damage.

What this showed in this study which was done at the University of North Carolina, Chappell Hill, that people who repeatedly took the maximum recommended daily dose of acetaminophen, which this is Tylenol brand, those type of medications, develop abnormalities in the blood test that can be a signal for liver damage. Importance of this study is very simply this, when we put anything unnatural in our body that was not designed to be there it is going to have a toxic affect to some extent. All these pain killers whether aspirin, acetaminophen, Cox 2 inhibitors, all these pain killers do have very significant side effects, as this study showed, this simple amount of just taking acetaminophen can cause liver damage. Why liver damage? Because your liver is the organ that detoxifies your body. Any chemical, drug, medication, anything that is not supposed to be in there, has to be detoxified by the liver. And the liver spends quite a bit of time, just taking care of the standard toxins that come from normal break down of food, break down of cellular metabolism. So, the endotoxins that come from the inside of the body have to be broken down. Now when we are adding exotoxins, which is from the outside of the body, this is from the air, water and food, eating food with chemical on it, injected hormones, concentrated toxins, as we up the food chain and eat animal products, eating highly sprayed plant material, non organic plant material, all this increases the chemical load, the toxic load, the liver has to deal with. So, all that combined is enough that the liver cannot keep up with it and when we add this on top of this adding more chemicals in the form of acetaminophen it just pushes it over the top and the liver will become damaged. It is important to know that the liver is the first organ to go out of balance before cancer develops so a primary alternative cancer treatment is necessary to keep the liver healthy. Also make sure you live the Seven Basic Steps to Total Health